Understand your creatinine result and why eGFR is important for kidney function interpretation.
Serum creatinine is a commonly ordered blood test, but it should not be interpreted alone. eGFR — calculated from creatinine, age and sex — gives a much more accurate picture of kidney filtration function.
Creatinine is a waste product produced constantly by the muscles during normal energy metabolism. It is filtered out of the blood by the kidneys and excreted in urine. When kidney function is reduced, creatinine builds up in the blood, causing the serum creatinine level to rise.
The "normal range" for serum creatinine varies widely between individuals. A serum creatinine that appears normal for one person may reflect significantly reduced kidney function in another — particularly in older adults, women, or people with low muscle mass. A creatinine of 1.0 mg/dL may reflect very different kidney function in a 25-year-old male athlete and an 80-year-old woman.
Serum creatinine is affected by:
Muscle mass: People with more muscle produce more creatinine. A bodybuilder may have a "high" creatinine but perfectly normal kidney function.
Age: Older adults typically have less muscle and therefore lower creatinine — but they may also have reduced kidney filtration.
Sex: Males generally have higher creatinine than females due to greater muscle mass.
Diet: A high-meat diet can temporarily raise creatinine.
Hydration: Dehydration can raise creatinine. Drinking large amounts of water may lower it temporarily.
Acute illness: Any acute illness can cause a temporary rise in creatinine.
Creatinine is reported in different units by different laboratories. Sri Lankan laboratories most commonly use mg/dL. Many international labs use µmol/L. The conversion is: µmol/L ÷ 88.4 = mg/dL. For example, 97 µmol/L ≈ 1.1 mg/dL.
Common questions about serum creatinine results and kidney function testing.
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